Manchester United midfielder Kobbie Mainoo will be one of four England players hoping to earn their senior debuts for the Three Lions in Saturday's friendly affair with Brazil at Wembley.
The 18-year-old wonderkid was selected for the Under-21s, whom he is yet to make an appearance for, before being swiftly promoted to Gareth Southgate's ranks for March's double-header with the Selecao and Belgium.
The uncapped quartet also comprises Ezri Konsa, Jarrad Branthwaite and Anthony Gordon, who will likely take their spots on the bench alongside Mainoo, while Arsenal's Bukayo Saka has been forced to pull out with an injury.
The 22-year-old was a notable absentee from team training on Wednesday, as were Cole Palmer, Jordan Henderson and Harry Kane, who hurt his ankle during Bayern Munich's recent Bundesliga win over SV Darmstadt 98, and the trio will not make the cut either.
With Three Lions captain being wrapped in cotton wool and also "extremely doubtful" for next week's meeting with Belgium, Aston Villa's Ollie Watkins and Brentford's Ivan Toney have the chance to fight it out for a starting role, a battle which the former should win.
With Saka and Palmer out, Jarrod Bowen is a candidate to occupy the right-wing position, while Marcus Rashford is in line to start on the left due to Jack Grealish's absence through injury.
A star-studded midfield trio of Phil Foden, Jude Bellingham and Declan Rice could very well grace the Wembley turf from the first whistle too, while Kyle Walker, John Stones, Harry Maguire and Jordan Pickford are mainstays at the back.
Ben Chilwell has been included in the squad despite a recent knee concern, but given his history of physical woes, Joe Gomez - recalled for the first time since 2020 - has a case to start at left-back, where he has done an exemplary job for Liverpool in recent months.
England possible starting lineup:
Pickford; Walker, Stones, Maguire, Gomez; Foden, Rice, Bellingham; Bowen, Watkins, Rashford
> Click here to see how Brazil could line up for this friendly
