The Catalan side have boosted their La Liga survival hopes by picking up four points from their last two matches, while Levante have collected two points from their last two fixtures.
Espanyol have not played outside of Spain's top flight since the 1993-94 campaign, while they finished seventh in La Liga last term, which is an indication of their standing at this level of football.
The Catalan outfit are facing the real threat of being relegated to the second tier for the 2020-21 season, although their form since returning to action earlier this month has been impressive.
Indeed, a 2-0 win over Alaves on June 13 was followed by a goalless draw at Getafe on Tuesday night, which has helped them move off the bottom of the table into 19th position.
Abelardo Fernandez's side are still in the relegation zone but are only three points off 17th-placed Celta Vigo and have more than enough time to move clear of the bottom three in the coming weeks.
Espanyol actually beat Levante in the reverse match earlier this season, while they recorded a 1-0 victory when the pair last locked horns at the RCDE Stadium in September 2018.
Levante have finished 15th in each of their last two seasons in Spain's top flight, having secured a return back to this level by winning the Segunda Division in 2016-17.
The Valencia-based outfit have enjoyed a solid campaign thus far, picking up 35 points from their 29 matches to sit 12th in the table, just four points off the top half of the division.
Paco Lopez's side have actually only lost one of their last five in the league, although they have recorded just one victory during that run, drawing their last three against Granada, Valencia and Sevilla.
No team in the bottom half of the table as won more La Liga matches than Levante (10) this term, although 14 defeats have cost them the chance to be higher up at this stage of the campaign.
Espanyol La Liga form: DLDLWD
Espanyol form (all competitions): LWDLWD
Levante La Liga form: LWLDDD
The hosts will hope that Naldo can overcome an injury problem of his own to replace Espinosa at the back, but there are not expected to be many other changes from the side that started last time out.
Ivan Lopez is still struggling through injury, but the visitors otherwise have a full complement of players heading into this weekend's contest at the RCDE Stadium.
Espanyol possible starting lineup:
Diego Lopez; Avila, Cabrera, Naldo, Vila; Embarba, David Lopez, Roca, Darder; Wu Lei, Calleri
Levante possible starting lineup:
Aitor; Coke, Bruno, Vezo, Tono; Bardhi, Melero, Vukcevic, Campana; Marti, Morales
We say: Espanyol 0-0 Levante
Levante have proved difficult to beat in their recent matches, while Espanyol have drawn four of their last six home league fixtures in Spain's top flight; we are finding it difficult to separate the two teams on Saturday afternoon and have therefore backed a goalless draw.