Fulham will be without Sasa Lukic and Timothy Castagne for Saturday's Premier League clash with Aston Villa at Craven Cottage.
Lukic sustained a serious shoulder ligament injury while on international duty with Serbia, while Castagne has returned from the Belgium team with a hamstring problem and Silva has confirmed that both players will not be involved this weekend.
Meanwhile, striker Carlos Vinicius is yet to play for Fulham this season due to a calf injury and is set to remain sidelined along with defender Jorge Cuenca (ankle).
Joachim Andersen withdrew from the Denmark squad during the international break due to an unspecified knock, but the defender has been passed fit to play on Saturday by Silva and is expected to start at centre-back alongside Calvin Bassey.
The absence of Lukic could see Emile Smith Rowe return to the starting lineup after he surprisingly began as a substitute in Fulham's 3-2 defeat at Manchester City prior to the international break.
Smith Rowe would presumably operate in the number 10 role behind either Raul Jimenez or Rodrigo Muniz - the latter of whom will be pushing to start up front after scoring off the bench last time out - while Alex Iwobi and ex-Villa winger Adama Traore are both expected to continue on the flanks.
Fulham possible starting lineup: Leno; Tete, Andersen, Bassey, Robinson; Berge, Pereira; Traore, Smith Rowe, Iwobi; Muniz
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