Meanwhile, the Accies have picked up four points from their last two away matches and could move out of the bottom two for the first time since September with a win at Easter Road.
Hibernian were unable to extend their winning run to four matches on Wednesday night as their fixture away at Ross County was postponed due to a frozen pitch.
After a dip in form which saw Hibs win just once in seven matches in all competitions between December 19 and January 11, the Edinburgh outfit have since won four of their last five league games and are on course to finish in the top four, with a 10-point gap separating them from Livingston in fifth.
Hibs have a good record against Hamilton, having won seven of their last eight league matches against them, drawing the other encounter 1-1 in October 2019.
With their next four games against teams in the bottom half of the table, Ross will be hoping that his side can finish the campaign strongly and edge towards the club's highest top-flight points total of 67, a tally accumulated during the 2017-18 season.
Hamilton extended their unbeaten run in the league to three matches after they drew 1-1 away at St Mirren on Wednesday evening.
Brian Rice's side now sit one point above Ross County at the bottom of the league and are level on points with Kilmarnock, having played a game less.
The Accies travel to Hibs after picking up five points from their last three matches, including an impressive 4-1 victory away at Motherwell last weekend.
Hamilton have, however, lost each of their last five away games at Easter Road in the Scottish Premiership since a 3-1 win back in August 2017.
Claiming three points on Saturday would see the Accies move out of the relegation playoff position and above Kilmarnock into 10th, three points behind St Johnstone, who they face next Wednesday.
Hibernian Scottish Premiership form: DWLWWW
Hibernian form (all competitions): WLLWWW
Hamilton Academical Scottish Premiership form: DLLDWD
Earlier this week, Hibs announced that one player has tested positive for coronavirus and is now self-isolating, although the player's identity has not yet been revealed.
Defender Aaron Martin, who picked up a foot injury against St Mirren, is doubtful for this weekend's match and will be assessed ahead of kickoff.
Rice could name the same starting lineup for the fourth successive game, which would see Marios Ogkmpoe partnering Anderson again in attack.
Hibernian possible starting lineup:
Marciano; McGinn, McGregor, Hanlon; Cadden, Gogic, Irvine, Doig; Murphy; Doidge, Boyle
Hamilton Academical possible starting lineup:
Fulton; Hamilton, Odoffin, Easton; Hodson, S. Martin, Trafford, McMann; Callachan; Anderson, Ogkmpoe
We say: Hibernian 2-2 Hamilton Academical
Hibs have beaten Hamilton twice already this season, scoring seven goals in the process, and after returning to form in recent weeks, they will fancy their chances of claiming all three points against them once again.
However, the Accies – who are desperate to escape the bottom two – have also improved of late and may prove to be more of a challenge for the hosts on Saturday.