Udinese vs. Bologna (Saturday, 2.00pm)
Both seeking to sneak into the top half of the table with a win, neither side has been in top form of late, so will now look to finish the season with a flourish.
We say: Udinese 1-1 Bologna
As both teams are virtually safe from the threat of relegation - needing only a point to be sure of survival - a draw could well be the outcome in Friuli.
The pair share a meagre goal threat at home and away respectively - Udinese have notched just 13 times at the Dacia Arena, while Bologna have bagged only 15 on the road - so efforts on target may be at a premium in a low-scoring draw.
Spezia vs. Napoli (Saturday, 2.00pm)
With four games to go, the visitors are embroiled in a fierce battle for a place in the Champions League, while their hosts are on a four-game winless streak which imperils their survival - despite an impressive debut Serie A campaign.
We say: Spezia 1-3 Napoli
Although Spezia are a tougher proposition on home soil, free-scoring Napoli can exploit their defensive deficiencies to take maximum points from an important fixture for both sides.
Thanks to their diverse attacking options, the Partenopei can gain a measure of revenge on their Ligurian hosts - who beat them at the Maradona - while staying in the hunt for a place at Europe's top table next term.
Inter Milan vs. Sampdoria (Saturday, 5.00pm)
After jubilant scenes in Italy's second city, the Nerazzurri return to Stadio Giuseppe Meazza looking to extend their formidable unbeaten run in Serie A, while mid-table Samp seek a rare league double over their Milanese counterparts.
We say: Inter Milan 1-1 Sampdoria
With neither side having a desperate need for points, a potentially relaxed feel to this encounter could lead to a somewhat surprise result - as Sampdoria can go undefeated against Inter this season with a draw.
The new champions have celebrated hard in recent days, so may concentrate more on savouring the Scudetto than extending their Serie A margin of victory.
Fiorentina vs. Lazio (Saturday, 7.45pm)
While the Aquile are top of the recent form table in Serie A, their hosts have won only once in their last seven outings to slip back into relegation trouble.
We say: Fiorentina 1-3 Lazio
Lazio justifiably come into this clash as strong favourites, with their undoubted quality in the final third set to help them brush aside their labouring opponents and secure maximum points on Saturday.
With only young Dusan Vlahovic proving a reliable source of goals this term, Fiorentina are often a lightweight proposition, so the Aquile can power on to an eighth win in nine - as a return to the Champions League remains a live possibility.
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