Sampdoria vs. Hellas Verona (Sunday, 11.30am)
Sampdoria host Hellas Verona on Sunday morning in a high-stakes scrap at the foot of the Serie A table.
Sitting rock-bottom and 18th respectively, Samp and Verona make up two of three teams in a relegation zone that is slipping further and further away from the rest of the top flight each week.
We say: Sampdoria 1-1 Hellas Verona
Samp have not won a home match all season, while Verona are yet to claim three points on the road this term; there is not a raft of evidence that either streak will end this weekend which suggests that this six-pointer may finish as a draw.
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Fiorentina vs. Lecce (Sunday, 2.00pm)
Following their European success in midweek, Fiorentina host an ailing Lecce side in Serie A on Sunday.
When the teams walk out at Stadio Artemio Franchi, the hosts will be aiming for a seventh straight win, while their Puglian visitors have lost each of their last three games without even scoring.
We say: Fiorentina 2-1 Lecce
Recent trends suggest there should be only one winner on Sunday, as Fiorentina are flying high and Lecce are at a low. While it may not be quite so straightforward given the Viola's European exertions, their forwards are full of confidence now - a total contrast with those of the visitors.
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Torino vs. Napoli (Sunday, 2.00pm)
After surging into the Champions League quarter-finals, Serie A leaders Napoli seek to add another domestic win to their collection on Sunday, when they tackle Torino.
Toro's last league win against the Partenopei dates back to 2015, and they will be hard pressed to end that run this weekend despite some good form keeping them in the hunt for a top-six finish.
We say: Torino 0-1 Napoli
Torino have conceded only eight goals at home, so Napoli's path to win 23 of the Serie A season is far from straightforward. As the Granata's defence generally stands firm under Ivan Juric, it could take a moment of magic to prise them open - but the Scudetto favourites are certainly capable of producing one of those.
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Lazio vs. Roma (Sunday, 5.00pm)
Separated by just two points and two places in the Serie A standings, capital city rivals Lazio and Roma clash at Stadio Olimpico on Sunday evening.
The 180th Derby della Capitale sees the Biancocelesti - who crashed out of Europe in midweek - leading the teams' tussle in the table, but victory would help Jose Mourinho's men climb back into the top four at their expense.
We say: Lazio 1-0 Roma
Both coaches have cited concerns over fatigue following their European exploits, but the two teams have had a similar workload in that regard. It may, therefore, be a cautious encounter decided by a single goal, and Lazio's ability to keep the back door shut could tip the balance in their favour.
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Inter Milan vs. Juventus (Sunday, 7.45pm)
After an eventful few months since they last met in November, old rivals Inter Milan and Juventus contest the 180th Serie A Derby d'Italia on Sunday.
Both sides progressed in Europe this week, but Inter lead Juve by a big margin in the standings following the Old Lady's points penalty and have held the upper hand in recent meetings.
We say: Inter Milan 2-2 Juventus
Inter have lost three of their last six Serie A matches following Champions League fixtures - including both of their last two - but they have had two days more to recover from their travels than Juventus.
In their final game before the international break, both sides will surely empty the tank in pursuit of Derby d'Italia glory, and there could well be a share of the spoils after an absorbing encounter at San Siro.
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