Salernitana vs. Hellas Verona (Wednesday, 5.30pm)
The two sides have never faced each other in the Italian top flight, though they have locked horns on 38 occasions in Serie B, with Verona winning 16 of those meetings.
We say: Salernitana 1-2 Hellas Verona
Both Salernitana and Verona will view this fixture as a winnable game, with the hosts desperate to get off the mark as a top-flight club.
The visitors, however, will be the favourites on Wednesday, and after securing an impressive win last weekend, we can see them taking their momentum to the Stadio Arechi and securing all three points.
Spezia vs. Juventus (Wednesday, 5.30pm)
The hosts, meanwhile, will be looking to claim their second triumph over the Old Lady, having previously won 3-2 against them when both sides competed in Serie B back in 2007.
We say: Spezia 1-3 Juventus
Juventus have already failed to win two Serie A matches against sides who finished in the bottom half of the table last season, so they cannot take Spezia lightly, especially as the hosts come into this fixture in high spirits.
The Aquilotti will be dreaming of a famous triumph over the Old Lady on Wednesday, however we expect Allegri's men to come out on top at the Stadio Alberto Picco.
Cagliari vs. Empoli (Wednesday, 7.45pm)
The hosts, meanwhile, have yet to claim all three points so far this season, accumulating just two from a possible 12 available.
We say: Cagliari 2-2 Empoli
Both sides will be keen to put together a good run of form in the coming weeks and will view Wednesday's fixture as a good opportunity to claim all three points.
However, with little to separate the two teams struggling in and around the relegation zone, an entertaining score draw could be on the cards at the Sardegna Arena.
AC Milan vs. Venezia (Wednesday, 7.45pm)
The two sides will meet for the first time since February 2002, when they Rossoneri claimed a 4-1 victory away from home.
We say: AC Milan 2-0 Venezia
AC Milan will be strong favourites to claim all three points on Wednesday, even though a number of first-team players are ruled out injured.
The hosts still have plenty of quality among their ranks and we expect them to secure a routine victory at San Siro, extending their unbeaten league run to five matches.