Ahead of the game, news of a regulation-breaking party which took place at on-loan midfielder Weston McKennie's home has jeopardised Pirlo's plans for the Derby della Mole.
As McKennie and fellow partygoer Paulo Dybala (who has only recently been passed fit after a heavily disrupted campaign) now facing exclusion as a result of their attendance - former Barcelona midfielder Arthur was also present but is injured in any case - Juve must adapt accordingly.
Furthermore, centre-back Giorgio Chiellini returned from Azzurri duty early having picked up a knock, so the ever-versatile Danilo may even be required to join Matthijs de Ligt at the heart of the Bianconeri's makeshift rearguard.
In Arthur's absence - plus that of McKennie, should he ultimately be dropped - midfield misfit Aaron Ramsey could be set to feature on Saturday, given the lack of other options for his manager.
Capocanonniere-chasing Cristiano Ronaldo returns from a controversial international period to lead the line for Juve, with Alvaro Morata favoured over Dejan Kulusevski to partner Portugal's record goalscorer up front.
Juventus possible starting lineup:
Szczesny; Danilo, Chiellini, De Ligt, Cuadrado; Bentancur, Ramsey, Rabiot, Chiesa; Morata, Ronaldo
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