Fenerbahce vs. Antwerp (Thursday, 5.45pm)
The hosts have picked up a single point in Group D and a victory has the potential to take them into second place, while the visitors head into this fixture having lost both of the opening matches.
We say: Fenerbahce 2-1 Royal Antwerp
Both teams need to secure three points in this fixture to keep the pressure on the two clubs above, which should lead to a closely-contested European tie.
However, with the home advantage on their side, Fenerbahce should have enough confidence to express themselves and create more chances against a squad that is known for conceding late goals.
Ludogorets vs. Braga (Thursday, 5.45pm)
The Bulgarian champions have lost five games in a row on home soil in the competition and could become just the third side to lose six on the spin after CSKA Sofia and Rosenborg.
We say: Ludogorets Razgrad 0-1 Braga
Ludogorets have a terrible home record in the Europa League, and we can see Braga becoming the latest side to come away from Huvepharma Arena with all three points.
The Portuguese visitors are not the highest scorers on their travels in Europe, but one goal should prove enough here.
Midtjylland vs. Red Star (Thursday, 5.45pm)
The Serbian champions have taken six points from six so far and lead the way at the top, while Midtjylland are bottom of the standings with just one point to their name.
We say: FC Midtjylland 0-2 Red Star Belgrade
Red Star are in superb form and will be confident of making it three wins from three in Group F in this first-ever meeting with Midtjylland.
Lazio vs. Marseille (Thursday, 5.45pm)
We say: Lazio 3-2 Marseille
Goals are surely there to be had between these two European powerhouses, although it has been a struggle for Marseille to translate their domestic firepower into continental results.
Real Betis vs. B. Leverkusen (Thursday, 5.45pm)
The hosts have lost only once on home soil so far this campaign, to Real Madrid, while the visitors have yet to suffer defeat on their travels, scoring 19 goals in the process.
We say: Real Betis 2-2 Bayer Leverkusen
An entertaining encounter, with plenty of goalmouth action, is to be expected between two of the Europa League's strongest sides at the Benito Villamarin.
Both teams will fancy their chances of claiming all three points; however, we feel that they may be forced to share the spoils on this occasion.
Rapid Vienna vs. Dinamo Zagreb (Thursday, 5.45pm)
The hosts currently sit bottom of Group H, having failed to win a match or score a goal in the opening two fixtures.
We say: Rapid Vienna 0-4 Dinamo Zagreb
These two teams are in contrasting form at the moment and that is something that will likely dictate the way this game goes, with the visitors likely to dominate.
The attacking prowess of Dinamo Zagreb has been clear to see in recent matches and they should have too much fire power for Rapid Vienna to handle.
Sparta Prague vs. Lyon (Thursday, 8.00pm)
The Ligue 1 outfit currently sit at the summit of Group A, two points clear of the Iron Sparta, who have claimed four points from their opening two fixtures.
We say: Sparta Prague 0-2 Lyon
A closely-fought contest is set to be played out on Thursday between two sides who are yet to concede in Group A, though Lyon will be the favourites to come out on top at the Generali Arena.
The French visitors should be strong enough to secure another victory, which would move them five points clear at the summit after just three games.
Rangers vs. Brondby (Thursday, 8.00pm)
The two sides, who will meet for the very first time in a competitive fixture, are two of only three teams who are yet to score in this year's competition.
We say: Rangers 2-1 Brondby
Although Rangers have struggled to put a consistent run of form together in recent weeks, Gerrard's side should have enough quality to claim all three points on Thursday.
Brondby should not be taken lightly, however, and could make it a challenging evening for the Gers, especially if they perform as well as they did against Sparta Prague.
PSV vs. Monaco (Thursday, 8.00pm)
While both clubs have managed to secure a draw with La Liga pacesetters Real Sociedad, defeat on Thursday could see either of these teams drop into third spot in Group B.
We say: PSV Eindhoven 1-1 Monaco
With the margins for error extremely small in this group, do not expect both sides to push forward at will. Nevertheless, this could prove to be an intriguing clash, one which could end in a share of the spoils.
Sturm Graz vs. Real Sociedad (Thursday, 8.00pm)
Real Sociedad square off against Sturm Graz on Thursday night still looking for their first win in this season's Europa League group stages.
However, Sociedad could move joint-top of Group B if they manage to overcome their Austrian hosts, who are yet to get a point on the board.
We say: Sturm Graz 0-2 Real Sociedad
With home advantage in their favour, Sturm Graz will likely throw a bit more caution to the wind during this contest. However, Sociedad's experience should prove key here, the visitors potentially running out victors with a clean sheet.
Napoli vs. Legia (Thursday, 8.00pm)
By contrast with their hosts, who have maintained a perfect record in the league but stuttered in Europe, group leaders Legia have lost their last two league games ahead of the trip to Naples.
We say: Napoli 2-1 Legia Warsaw
Whether Napoli can secure their first win this week will depend heavily on selection, as a full-strength team in top gear would prove more than a match for a Legia side who have lost three of their last four.
Frankfurt vs. Olympiacos (Thursday, 8.00pm)
The top two teams in Group D will collide on Thursday as Eintracht Frankfurt look to overtake their opponents and continue their undefeated start to the 2021-22 Europa League competition.
However, that will not be an easy feat, with Olympiacos having won both of their games so far as they head into this fixture with an 11-match unbeaten streak in all competitions.
We say: Eintracht Frankfurt 1-2 Olympiacos
Both teams are in good form when it comes to their respective leagues and because of that they will each head into this fixture with plenty of confidence.
However, Olympiacos are likely to just edge this game, which is a victory that would give them a fantastic chance of qualifying from the group.
Lokomotiv vs. Galatasaray (Thursday, 8.00pm)
Galatasaray will seek to cement their position atop the Europa League Group E rankings when they travel to Lokomotiv Moscow for Thursday evening's battle.
Fatih Terim's side played out a goalless stalemate with Marseille in their most recent continental clash, while the hosts suffered a 2-0 defeat to Lazio.
We say: Lokomotiv Moscow 0-1 Galatasaray
Both Galatasaray and Lokomotiv have posted far too many draws for each manager's liking so far this season, and we would not put it past another share of the spoils here.
West Ham vs. Genk (Thursday, 8.00pm)
The Hammers have won both games so far without conceding a goal, while the visitors currently find themselves in third place after one victory and a loss.
We say: West Ham United 2-0 Genk
The Hammers will be likely to continue their perfect start to the group on Wednesday as they face a team who have been struggling as of late to create chances.
Because West Ham United have not conceded in Group H yet and have the advantage of being at home, there is a good chance that they should be able to stay on top.
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