SM
| Venue: Emirates Stadium |
Arsenal | ||
| G | 19 | Bernd Leno |
| CD-L | 5 | Sokratis Papastathopoulos |
| CD-R | 20 | Shkodran Mustafi |
| LB | 31 | Sead Kolasinac |
| RB | 12 | Stephan Lichtsteiner S  |
| AM | 8 | Aaron Ramsey S |
| LM | 34 | Granit Xhaka |
| RM | 11 | Lucas Torreira |
| F | 9 | Alexandre Lacazette |
| AM-L | 17 | Alex Iwobi S |
| AM-R | 7 | Henrikh Mkhitaryan |
| Sub | 6 | Laurent Koscielny |
| Sub | 10 | Mesut Özil |
| Sub | 14 | Pierre-Emerick Aubameyang |
| Sub | 1 | Petr Cech |
| Sub | 18 | Nacho Monreal |
| Sub | 22 | Denis Suárez |
| Sub | 29 | Matteo Guendouzi |
Southampton | ||
| G | 28 | Angus Gunn |
| CD | 5 | Jack Stephens S |
| CD-L | 4 | Jannik Vestergaard |
| CD-R | 35 | Jan Bednarek |
| CM-L | 16 | James Ward-Prowse |
| CM-R | 23 | Pierre-Emile Højbjerg |
| AM | 14 | Oriol Romeu |
| LM | 33 | Matt Targett |
| RM | 43 | Yann Valery |
| F | 22 | Nathan Redmond |
| RCF | 17 | Stuart Armstrong |
| Sub | 10 | Charlie Austin |
| Sub | 21 | Ryan Bertrand |
| Sub | 3 | Maya Yoshida |
| Sub | 1 | Alex McCarthy |
| Sub | 55 | Callum Slattery |
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