Brugge vs. Man City (Tuesday, 5.45pm)
Club Brugge will somehow attempt to claim another memorable Champions League scalp when they play host to Manchester City in Group A on Tuesday night.
Philippe Clement's side claimed an impressive 2-1 win over RB Leipzig on matchday two, while City fell to a dampening defeat against Paris Saint-Germain.
We say: Club Brugge 0-2 Manchester City
Brugge command plenty of respect seeing as they sit above City in the embryonic Group A rankings, but masterminding a victory over Guardiola's men may be a step too far for Clement.
The visitors have plenty of options for rotation and will not accept anything less than three points after their Paris setback, so we can only envisage City coming out on top and breaking Brugge's resistance.
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> How Man City could line up against Club Brugge
> Man City injury, suspension list vs. Club Brugge
Besiktas vs. Sporting Lisbon (Tuesday, 5.45pm)
Yet to get off the mark in the Champions League this term, Group C outsiders Besiktas and Sporting Lisbon meet in Istanbul on Tuesday.
Neither side has picked up a point from games against Ajax and Borussia Dortmund, so will be desperate to come out on top in the first of back-to-back matches between the champions of Turkey and Portugal.
We say: Besiktas 2-3 Sporting Lisbon
Both sides pose a threat in the final third and are capable of causing each other some serious defensive problems on Tuesday.
With everything to play for and several able attackers on display, the game should open up after its first goal, and Sporting can edge out their hosts by the odd goal due to shortcomings in the Besiktas back line.
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PSG vs. RB Leipzig (Tuesday, 8.00pm)
Paris Saint-Germain will hope to secure their second consecutive victory in the Champions League when they welcome RB Leipzig to the Parc des Princes for Tuesday's Group A battle.
Mauricio Pochettino's side marched to a 2-0 win over Manchester City in their most recent European contest, while the German side fell to a dampening defeat against Club Brugge.
We say: Paris Saint-Germain 3-1 RB Leipzig
With Nkunku on song and determined to get one over his former club, Leipzig have no woes on the attacking front to contend with, but the odd consolation goal may be where the visitors' joy ends.
PSG's South American stars will be well-rested and will need no second invitation to pile more misery on Leipzig, so we are backing Pochettino's side to get the job done convincingly.
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> How PSG could line up against RB Leipzig
> PSG injury, suspension list vs. RB Leipzig
Atletico vs. Liverpool (Tuesday, 8.00pm)
Liverpool will endeavour to continue their perfect start to the 2021-22 Champions League when they travel to Atletico Madrid for Tuesday's Group B encounter.
Jurgen Klopp's side produced a five-star performance to thrash Porto 5-1 on matchday two, while Atletico claimed a last-gasp win over AC Milan.
We say: Atletico Madrid 1-2 Liverpool
Very rarely will Atletico fans witness their side ship multiple goals on home soil, but the fired-up Reds trio can exploit their hosts' defensive deficiencies as Simeone is forced to rejig his backline.
The extended rest ought to help the La Liga champions break Liverpool's resilience, but Klopp's attackers are on top of their game at the moment and should help to propel the Reds to another European win.
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> How Liverpool could line up against Atletico Madrid
> Liverpool injury, suspension list vs. Atletico
Porto vs. AC Milan (Tuesday, 8.00pm)
Two sides still searching for their first wins of the 2021-22 Champions League prepare for battle at the Estadio do Dragao on Tuesday, as Porto face off against AC Milan in Group B.
Sergio Conceicao's side were blown away by Liverpool 5-1 last time out, while the Rossoneri suffered an agonising last-minute defeat to Atletico Madrid.
We say: Porto 1-1 AC Milan
Porto will certainly sense an opportunity to get one over the Rossoneri given their injury crisis, and Conceicao's side held their own against Atletico before being blown away by Liverpool.
Milan's Champions League campaign is at risk of ending before it has even begun, but we still expect an injury-hit Rossoneri - on a high from their dramatic win over Verona - to do enough to come away with a point from the Estadio do Dragao.
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Ajax vs. Dortmund (Tuesday, 8.00pm)
Something must give when Group C's top two clash in the Champions League on Tuesday, as Ajax welcome Borussia Dortmund to Amsterdam.
Both sides have claimed maximum points from their first two fixtures against Besiktas and Sporting, so will go head-to-head in the first of consecutive meetings which could decide their destiny.
We say: Ajax 2-1 Borussia Dortmund
Home advantage and an abundance of attacking options can help Ajax exploit their visitors' defensive deficiencies this week, claiming a vital victory that would put them within touching distance of qualification already.
Dortmund certainly pose a threat of their own on the break, but may be caught out when pushing forward and can be picked off in wide areas by the hosts' guileful frontmen.
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Shakhtar vs. Real Madrid (Tuesday, 8.00pm)
Real Madrid will be looking to return to winning ways in the Champions League when they head to Ukraine on Tuesday night to take on Shakhtar Donetsk in Group D.
Los Blancos are currently second in the section, picking up three points from two matches, while Shakhtar have collected just one point from their two games to sit at the foot of the table.
We say: Shakhtar Donetsk 1-2 Real Madrid
This is a very tough match for Real Madrid, who were shocked by Sheriff in their last Champions League fixture. Shakhtar are more than capable of picking up a positive result on Tuesday night, but we are backing Real Madrid's quality to just shine through in order to claim an important three points.
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> How Real Madrid could line up against Shakhtar Donetsk
> Real Madrid injury, suspension list vs. Shakhtar
Inter Milan vs. Sheriff Tiraspol (Tuesday, 8.00pm)
Sheriff Tiraspol will be looking to make it three straight victories in Group D when they continue their Champions League campaign away to Italian giants Inter Milan on Tuesday.
A total of six points from two games has incredibly left tournament debutants Sheriff at the top of the section, while Inter are third, having collected just one point from their opening two fixtures.
We say: Inter Milan 2-1 Sheriff Tiraspol
Sheriff have been outstanding in the competition this season but might come up just short in this match. Inter will be desperate to get their Champions League campaign up and running following two disappointing results, and we are expecting the Italian champions to shade a close contest at San Siro.
