Liverpool need to beat Napoli by three or more goals on Tuesday in order to overtake them into top spot in Group A of the Champions League.
The visitors, meanwhile, head to Anfield having put together a remarkable 13-match winning streak in all competitions, and they will be aiming to maintain their 100% record in this season's competition.
Here, Sports Mole rounds up Liverpool's latest injury and suspension news ahead of their clash with Napoli.
Status: Out
Type of injury: Knee
Possible return date: December 26 (vs. Aston Villa)
Luis Diaz suffered a serious knee injury against Arsenal earlier this month, and the Colombia winger will not feature for the club again until after the end of the upcoming World Cup.
Status: Out
Type of injury: Calf
Possible return date: November 6 (vs. Tottenham Hotspur)
Joel Matip sustained a calf injury during the 3-2 defeat at the Emirates Stadium, with the central defender fighting a race against time to be available again before the World Cup.
Status: Out
Type of injury: Thigh
Possible return date: November 6 (vs. Tottenham Hotspur)
Naby Keita has resumed training following a serious calf injury which has kept him out for the majority of the campaign, but he was not included in Liverpool's Champions League squad and therefore may be targeting a return away to Tottenham on Sunday.
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Arthur underwent surgery on a serious thigh injury earlier this month and it remains unclear when the midfielder, who is on loan for the season from Juventus, will be available again.
Status: Out
Type of injury: Calf
Possible return date: December 26 (vs. Aston Villa)
Diogo Jota suffered a serious calf injury in the dying stages of his side's 1-0 win against Manchester City earlier this month, with the Portugal forward ruled out of the World Cup as a result.
LIVERPOOL'S SUSPENSION LIST
Liverpool have no players suspended for the clash with Napoli.
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