Real Madrid manager Zinedine Zidane has a fresh defensive injury concern to work around for the second leg of his side's Champions League quarter-final with Liverpool on Wednesday night.

Los Blancos travel to Anfield boasting a 3-1 lead from the first leg, but Zidane lost makeshift right-back Lucas Vazquez to injury during El Clasico at the weekend, and the soon-to-be free agent has been ruled out for the foreseeable with a cruciate ligament sprain.

With Dani Carvajal not ready to return from a hamstring problem, Alvaro Odriozola - only just back from injury himself - is set to occupy the right-hand side as he does his best to keep Sadio Mane quiet on Merseyside.

Sergio Ramos has not recovered from a calf problem and recently contracted COVID-19, while Raphael Varane returned a positive coronavirus test before the first leg, so Nacho Fernandez and Eder Militao are set to form the centre-back pairing on Wednesday.

Casemiro's red card in El Clasico does not affect his participation here, and the Brazilian will once again line up with Toni Kroos - who shone in the first leg - and Luka Modric, who could make history for Real Madrid if he registers an assist for the fourth Champions League game in a row.

Federico Valverde also had to be withdrawn at the weekend with a bruised foot, which should not keep him out of this game, but Marco Asensio is sure to return here after his goal in the first leg.

Karim Benzema will lead the line as he looks to build on the four strikes he already boasts against Liverpool, while the hero of the first leg - Vinicius Junior - will complete Zidane's front three as the injury-plagued Eden Hazard remains out of action.

Real Madrid possible starting lineup:
Courtois; Odriozola, Nacho, Militao, Mendy; Casemiro, Kroos, Modric; Asensio, Benzema, Vinicius Jr

> Click here to see how Liverpool could line up for this clash