Emre Can misses out due to suspension, while Alex Oxlade-Chamberlain has dropped to the bench and Joel Matip has been axed at the back in favour of Lovren, who will partner Virgil van Dijk on the Dutchman's Champions League debut.
Ragnar Klavan has returned to fitness after recovering from a thigh injury, but he has not been included in the squad, while Joe Gomez has not been included in the starting side due to a recent injury niggle.
Porto: Jose Sa; Ricardo, Reyes, Marcano, Alex Telles; Herrera, Sergio; Otavio, Brahimi, Marega; Soares
Subs: Casillas, Pereira, Osorio, Oliver, Corona, Waris, Paciencia
Liverpool: Karius; Alexander-Arnold, Van Dijk, Lovren, Robertson; Milner, Henderson, Wijnlaudm; Salah, Mane, Firmino
Subs: Mignolet, Gomez, Moreno, Oxlade-Chamberlain, Lallana, Ings, Matip
Discover how the match unfolds in Sports Mole's live commentary here.