A win against Russian opposition tonight will confirm the Reds as Group E champions, while a point would be enough to see them through to the next stage.
As for the visitors, Massimo Carrera makes six changes from the starting XI that managed a 1-0 win over Arsenal Tula in the Russian Premier League last Friday, handing Cape Verdean forward Ze Luis a start up front.
There is one change in the back four, with Serdar Tasci replacing Ilya Kutepov as centre-half partner for Salvatore Bocchetti, alongside Andrey Yeshchenko on the right and Georgi Dzhikiya at left-back.
Aleksandr Selikhov is in for Aleksandr Maksimenko in goal.
Liverpool: Karius; Gomez, Klavan, Lovren, Moreno; Can, Wijnaldum, Coutinho; Mane, Salah, Firmino
Subs: Mignolet, Milner, Henderson, Sturridge, Oxlade-Chamberlain, Solanke, Alexander-Arnold
Spartak Moscow: Selikhov; Eshchenko, Tasci, Bocchetti, Dzhikiya; Fernando, Glushakov; Zobnin, Adriano, Promes; Ze Luis
Subs: Rebrov, Kutepov, Samedov, Melgarejo, Pasalic, Popov, Pedro Rocha
Keep up with all of the action from Anfield tonight with Sports Mole's live text commentary here.