However, the North London side will head into the game buoyed by an improved performance against Red Star Belgrade on Tuesday which saw them earn a 5-0 win.
Here, Sports Mole rounds up Tottenham's latest injury and suspension news ahead of Sunday's showpiece meeting with the Reds.
Type of injury: Elbow
Possible return date: Unknown
You knew almost immediately that something was wrong when Lloris landed at an awkward angle after conceding against Brighton earlier this month. The Frenchman is not expected to make a return until the New Year as he continues to recover from damaging the ligaments in his elbow.
Type of injury: Hamstring
Possible return date: November 3 (vs. Everton)
Continued hamstring problems, something dating back to the summer, has so far precluded Sessegnon from making his Spurs debut, but the youngster is training with the group and coming closer to full fitness, although Sunday's game is likely to come too early for him.
TOTTENHAM HOTSPUR'S SUSPENSION LIST
Spurs have no players suspended for this match.
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