The hosts dropped their first points of the season at the ninth time of asking last time out, but they returned to winning ways in midweek and take on a Spurs side struggling for form so far in 2019-20.
The outcome of a Champions League final is always as polarising as it gets in club football, but the way teams respond to their respective fortunes can vary greatly.
So far this season, Liverpool seem to have picked up exactly where they left off in Madrid, whereas Tottenham have suffered a vicious hangover which is still very much being felt five months later.
The feeling that last season may have been the peak of this Spurs team could well have engendered a desire to leave the club for many of their star players whose contracts are nearing an end, which is one of a growing list of reasons given for such a poor start to the season.
Compare that to Liverpool, who have swept almost all before them so far this term, and within less than half a year the two-goal margin which ultimately separated them in Madrid has stretched to a 13-point lead after only nine games of the Premier League season.
Such a disparity between the two sides should be kept in context; Liverpool have enjoyed a historically good start to the season - victory on Sunday would see them equal the Premier League record of 28 points from the first 30 available - whereas Spurs have amassed their lowest points tally at this stage of a season since Pochettino took charge in 2014-15.
Both can be regarded as anomalies to a certain extent, then, but Liverpool will still go into the match as overwhelming favourites given what had been, up to last weekend, a faultless start to the season.
The Reds fell short of the top-flight record of 18 successive wins at Old Trafford and came within five minutes of losing just their second league game in 48 before Adam Lallana at least rescued a point at the end of an uncharacteristically turgid display at the home of their greatest rivals.
The draw may have ended their perfect start to the campaign, but they are still unbeaten in 26 league games and returned to winning ways with an overdue away Champions League group-stage triumph over Genk in midweek.
Liverpool's travel sickness has been nowhere near as bad in the league as it has been in Europe recently, but there is no doubt that they are still most formidable in front of their own fans.
Indeed, Jurgen Klopp's side go into this match having gone 44 league games without defeat at Anfield, the last 11 of which have all ended in victory - the club's longest home winning streak since a run of 13 in 1985.
Anfield is a daunting place to visit for any team in world football right now, then, but Spurs in particular will be dreading the trip having failed to win an away game of any kind all season - the last three of which have all ended in defeat.
Remarkably, you have to go all the way back to January for Tottenham's last league win on the road, during which time they have picked up two points from a possible 30. The last time Spurs went more than 10 away league games without a win was in 2000-01.
Some encouragement can be drawn from the fact that those two points came away to Manchester City and Arsenal, but Spurs have also lost 20 and failed to win any of their last 23 Premier League games against the team starting the day top of the table.
Recent history seems to be against the visitors, then, and on current form it would take a major upset for Spurs to get something out of the game - Liverpool have more than double the number of points this season and seem to be a squad in sync compared to the disharmony around Spurs.
It was a welcome relief for a side that had only won twice in 12 games since the opening day of the season, and the return to form of such key players will have also been a significant milestone on Pochettino's road back to glory.
Liverpool at Anfield is an entirely different proposition, though, and certainly not the ground Spurs would have chosen to finally end their away duck.
Liverpool Premier League form: WWWWDW
Recent form (all competitions): WWWWDW
Tottenham Premier League form: DWLWLD
Recent form (all competitions): LWLLDW
Liverpool left defensive pair Joel Matip and Trent Alexander-Arnold out of their travelling party for Genk in midweek, but the latter at least is expected to return from his illness in time for this one.
With Xherdan Shaqiri and Nathaniel Clyne still absent, that leaves the only other major decision for Klopp to make in midfield, with Jordan Henderson, James Milner, Naby Keita, Alex Oxlade-Chamberlain and Adam Lallana all competing for three places.
Perhaps the biggest decision for Pochettino will be whether he switches formation to the same 3-4-3 which caused Liverpool problems against United, although a similar system did not work entirely well for Spurs against Watford late timeout.
Liverpool possible starting lineup:
Alisson, Alexander-Arnold, Lovren, Van Dijk, Robertson; Oxlade-Chamberlain, Fabinho, Wijnaldum; Salah, Firmino, Mane
Tottenham possible starting lineup:
Gazzaniga; Alderweireld, Sanchez, Vertonghen; Aurier, Ndombele, Winks, Rose; Alli; Kane, Son
Head To Head
Liverpool have dominated the recent history of this fixture, winning 10 and losing just one of the last 15 meetings across all competitions.
That includes victories in all three games last season, and should Klopp's side avoid an upset on Sunday then it would be the first time they have won four games in a row against Spurs since 2015.
You have to go back to 2011 for Tottenham's last winning visit to Anfield - a run of eight games which includes five defeats.
We say: Liverpool 2-0 Tottenham
It is hard to see past a Liverpool win in this match - not only because of the start both teams have made to the season but also due to the alarming disparity between their respective home and away records. It is a tricky match on paper, but we expect Liverpool to ease to a relatively comfortable victory.