Jamie Carragher captains the home side in his last game before his retirement and 17-year-old Jordan Ibe makes his Liverpool debut against Queens Park Rangers.
QPR defender Michael Harriman makes his Premier League debut for the club, as Loic Remy retains his place in the strating XI despite being arrested on suspicion of rape on Wednesday.
Liverpool are missing Steven Gerrard and Daniel Agger through injury, while top scorer Luis Suarez is serving a 10-match ban for biting Chelsea's Branislav Ivanovic.
Liverpool: Reina; Johnson, Enrique, Carragher, Skrtel; Lucas, Henderson, Coutinho; Downing, Ibe, Sturridge
QPR: Green; Harriman, Onuoha, Hill, Traore; Park, Derry, Mbia, Townsend; Remy, Zamora