Everton interim boss David Unsworth has made numerous changes for the club's Europa League clash in Lyon.
Unsowrth had already left Phil Jagielka, Leighton Baines and Wayne Rooney on Merseyside, but alterations have been made all over the pitch ahead of the showdown with the Ligue 1 outfit.
Cuco Martina and Mason Holgate have come into the defence, with Morgan Schneiderlin and Beni Baningime featuring in the centre of midfield alongside Idrissa Gueye.
Ademola Lookman gets a rare start on the flank, while Gylfi Sigurdsson is included as Everton's main striker after only starting the Premier League game at Leicester City on the bench.
As for Lyon, Memphis Depay and Bertrand Traore are both handed starts in attack, as is Nabil Fekir who has scored five goals in his last three games.
Lyon head into the game with a four-point advantage over Everton, and victory will be enough to eliminate the Premier League side from the competition.
Lyon: Lopes; Rafael, Marcelo, Diakhaby, Mendy; Tousart, Ndombele, Cornet, Fekir, Depay; Traore
Everton: Pickford; Kenny, Martina, Williams, Holgate; Schneiderlin, Baningime, Gueye, Lennon, Lookman; Sigurdsson
Subs: Robles, Mirallas, Klaassen, Besic, Vlasic, Calvert-Lewin, Feeney
Follow the game from France with Sports Mole's live commentary.