Spanish hosts Malaga have never faced an Italian side in a competitive encounter.
Despite this being only their second ever European campaign, the Andalusians have started the Champions League group stages brightly with two wins from two matches.
However, for the visit of AC Milan on Wednesday night, they will be without the midfield trio of Diego Buonanotte, Julio Baptista and Jeremy Toulalan.
Left-back Nacho Monreal will also require a fitness test, although reports have claimed that he should be passed to play.
The visiting Italians are likely to be without former Manchester City attacker Robinho, who picked up a thigh strain during a recent training session.
Meanwhile, veteran midfielder Massimo Ambrosini is in line to make his first Champions League appearance of the season.
Recent form
Malaga: WLWWD
AC Milan: LLWDW
Possible starting lineups:
Malaga: Caballero; Gamez, Weligton, Demichelis, Monreal; Camacho; Joaquin, Isco, Portillo, Eliseu; Saviola
AC Milan: Amelia; De Sciglio, Bonera, Zapata, Antonini; Ambrosini, Emanuelson, Montolivo, Boateng; Pazzini, El Shaarawy
Sports Mole says: 2-1
