Borussia M'bach vs. Man City (Wednesday, 8.00pm)
It is the first time that Gladbach have competed in the knockout stages of the Champions League, although they did reach the final of the old European Cup in 1977, while Man City are looking to win the competition for the first time in the club's history.
We say: Borussia Monchengladbach 0-2 Manchester City
Given the lack of home advantage for Gladbach and the contrasting form between the two sides, we can envisage a comfortable win for Man City.
It is tough to see Rose's side even scoring past Man City, let alone gaining a positive result to realistically keep themselves in the tie.
Atalanta vs. Real Madrid (Wednesday, 8.00pm)
Gian Piero Gasperini's side finished second in Group D to book their spot in the knockout stages, while Real Madrid ultimately topped Group B after a shaky start to proceedings.
We say: Atalanta BC 3-1 Real Madrid
A full-strength Real Madrid would be capable of making the first leg a truly tantalising battle, but Los Blancos' decimated defence will no doubt struggle to contain Atalanta's rampant attacking contingent.
The hosts' rearguard is not impenetrable by any means, but Gasperini's men will smell blood and we expect them to march to a historic triumph over their opponents before they travel to Madrid for the second leg next month.