Guardiola believes his side will be determined to make amends after their frustrating quarter-final exit at the hands of Lyon last term.
City can secure their place in the knockout stages for an eighth consecutive year with victory over Olympiacos in Greece on Wednesday.
"Even when the situation is normal – no winter breaks, a lot of games, a lot of competitions, intensity, the weather conditions, the pitches – many, many things.
"But that is attractive and the challenge is this one. When you are able to do it, that is nice."
Sergio Aguero, Fernandinho and Benjamin Mendy are all back in contention for City after recent lay-offs.