After comfortably seeing off West Ham United on Wednesday, second-placed City now hold a four-point advantage over their hosts at the weekend.
However, Pep Guardiola has a couple of selection dilemmas ahead of this fixture, aware that City square off against Real Madrid in the Champions League and Aston Villa in the EFL Cup final next week.
Here, Sports Mole rounds up City's latest injury and suspension news ahead of playing the Foxes.
Status: Minor doubt
Type of injury: Knee
Possible return date: February 22 (vs. Leicester)
Having recently spent time training with the rest of his teammates, Sane is believed to be closing in on a return from a serious knee injury. With Guardiola unlikely to consider Sane for Wednesday's showdown in Spain, do not be surprised to see the German feature on the substitutes' bench at the weekend.
Status: Major doubt
Type of injury: Hamstring
Possible return date: February 22 (vs. Leicester City)
While Sterling is making progress from the hamstring injury sustained at Tottenham Hotspur at the beginning of the month, Guardiola is unlikely to risk the fitness of the England international, who may have a chance of returning against Madrid.
MAN CITY'S SUSPENSION LIST
With Oleksandr Zinchenko having serving his one-match ban, City have no players who are suspended for this contest.
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