Pep Guardiola's side have dominated domestic cup competitions in recent years, particularly the League Cup which they could win for a fifth time in seven seasons.
Fresh from a famous 2-1 comeback win away to Real Madrid on Wednesday night, City will be favourites to add another piece of silverware to their growing cabinet having hammered the same opposition 6-1 less than two months ago.
Here, Sports Mole looks at how Guardiola could line his side up for the contest.
Perhaps the only negative to come from the midweek win at the Bernabeu was an injury suffered by Aymeric Laporte, who is now set for up to a month on the sidelines.
As was the case in Madrid, Fernandinho is expected to replace the Frenchman alongside Nicolas Otamendi at the heart of the defence, and Guardiola is also likely to recall a number of familiar faces who were surprisingly left out in the Spanish capital.
The Argentine has a formidable record against Villa, scoring five goals in the last three meetings including a hat-trick when the two sides last met in January.
> Click here to see how Aston Villa could line up for this contest body check tags ::