The Citizens dominated possession but struggled to break their newly-promoted opponents down for large parts, testing Mathew Ryan on just a couple of occasions before their opener eventually arrived.
Relive how the 90 minutes of action unfolded with Sports Mole's live text coverage below.
STARTING XI: Ryan; Bruno, Dunk, Duffy, Suttner; Brown, Propper, Stephens, March; Gross; Hemed
SUBS: Maenpaa, Huenemeier, Rosenior, Sidwell, Murphy, Knockaert, Murray
STARTING XI: Ederson; Walker, Stones, Kompany, Otamendi, Danilo; Fernandinho, Silva, De Bruyne; Jesus, Aguero
SUBS: Bravo, Bernardo, Sterling, Sane, Mangala, Foden, Toure
Chris Hughton: "[City] have been outstanding in pre-season, and if we're looking at a team gelling and showing the quality that they have, they have definitely shown that already. It's a wonderful game for the club and supporters, as a first game in the Premier League, but we have to make sure it's a good day for the team as well."
Pep Guardiola: "Hopefully next season I will be here. If so, we won't spend like this season, I assure you of that. The club never bought full-backs in seven years. Man City had one of the oldest teams in Europe. The market is what it is."
BRIGHTON & HOVE ALBION SUBS: Maenpaa, Huenemeier, Rosenior, Sidwell, Knockaert, Murray
MANCHESTER CITY SUBS: Bravo, Bernardo, Sterling, Sane, Mangala, Foden, Toure