Pep Guardiola's side have been in mercurial form of late, alternating between away defeats at Chelsea and Southampton and big home wins against Burnley, Liverpool and Newcastle United.
Another win on Saturday would guarantee a top-four finish for the former champions, but they arrive on the South Coast in the midst of Guardiola's worst away run as a manager.
Here, Sports Mole looks at how the visitors could line up for the contest as they look to stop the rot on their travels.
Out: Sergio Aguero (knee)
Picking a Guardiola XI is an exercise in guesswork at the best of times, yet alone with little riding on Premier League games and much more important matters such as the FA Cup and Champions League to come.
Guardiola has made more changes to his starting lineup than any other manager in the Premier League this season and more are expected here, although the standard of performance against Newcastle could convince him to keep some star names in.
David Silva would be at the top of that list as he showcased his enduring class with a stunning display, registering a goal, two assists and completing 106 of his 112 passes.
The strength in depth at Guardiola's disposal means that changes are inevitable, though, with an entirely new back four of Kyle Walker, Aymeric Laporte, Eric Garcia and Benjamin Mendy able to be recalled.
Mendy and De Bruyne were minor injury doubts, although they both trained along with the rest of the squad on Friday morning and so should be in contention.