Table toppers Manchester City will be seeking their 13th successive Premier League victory when they travel to St Mary's to face Southampton on Saturday evening.
Meanwhile, the Saints, who secured a point at the Etihad Stadium earlier this campaign, will be hoping to avoid defeat in both league meetings with the Citizens for the first time since 2002-03, and here, Sports Mole rounds up the team news for both clubs.
SOUTHAMPTON vs. MANCHESTER CITY
SOUTHAMPTON
Out: Theo Walcott, Mohamed Elyounoussi (both COVID-19), Valentino Livramento (knee), William Smallbone (calf), Alex McCarthy (thigh), Moussa Djenepo (international duty)
Doubtful: None
Sports Mole's predicted XI: Forster; Bednarek, Lyanco, Salisu; Walker-Peters, Diallo, Romeu, Ward-Prowse, Perraud; Adams, Broja
MANCHESTER CITY
Out: Oleksandr Zinchenko (knock), Riyad Mahrez (international duty), Benjamin Mendy (club suspension)
Doubtful: Cole Palmer (fitness)
Sports Mole's predicted XI: Ederson; Walker, Dias, Laporte, Cancelo; De Bruyne, Rodri, B. Silva; Jesus, Foden, Sterling