Manchester United manager David Moyes will oversee arguably his biggest game in charge of the club so far on Wednesday when the Red Devils host Olympiacos for the second leg of their Champions League last-16 tie.

United have it all to do at Old Trafford after slumping to a 2-0 defeat in Greece two weeks ago.

Moyes has been under increasing pressure in recent weeks following just two wins in six matches.

An exit from the competition on Wednesday is sure to see the Scot face yet more questions over his future, but another poor performance could prove even more damaging.

However, Moyes and his players should be boosted by the fact that Olympiacos have lost all seven of their previous matches in England.

Chris Smalling and Jonny Evans are both unavailable for United through injury, while the cup-tied Juan Mata also misses out. Moyes has already confirmed that Shinji Kagawa will play a part at some point.

Meanwhile, Olympiacos will be without the injured pair of Michael Olaitan and Dimitris Siovas.

Recent form

Man Utd: DDWLWL

Olympiacos: WWWLLW

Possible starting lineups

Man Utd: De Gea; Rafael, Vidic, Jones, Evra; Fellaini, Carrick; Kagawa, Rooney, Januzaj; Van Persie

Olympiacos: Jimenez; Salino, Manolas, Marcano, Holebas; Fuster, Maniatis, Dominguez, Ndinga, Perez; Campbell

Sports Mole says: 2-1