Liverpool have been drawn to face Everton in the FA Cup third round, less than a week before the teams do battle at Anfield in the Premier League.
Manager Jurgen Klopp has previously used cup competitions to rotate his squad, but the German may now be forced to play his star names against the club's city rivals.
Premier League leaders Manchester City will host Burnley, while Manchester United have been handed a home meeting with Championship side Derby County.
Holders Arsenal must travel to the City Ground to face Nottingham Forest, while AFC Wimbledon will visit Wembley Stadium to take on Tottenham Hotspur.
Chelsea will travel to East Anglia to take on Norwich City, with fellow Championship side Wolverhampton Wanderers being drawn at home to play Swansea City.
Brighton & Hove Albion will take on rivals Crystal Palace at the Amex Stadium, and Middlesbrough and Sunderland will contest the North-East derby at the Riverside Stadium.
All of the ties will be played between January 5 and January 8.
Full draw
Ipswich Town vs. Sheffield United
Watford vs. Bristol City
Birmingham City vs. Burton Albion
Liverpool vs. Everton
Brighton & Hove Albion vs. Crystal Palace
Aston Villa vs. Woking or Peterborough
Bournemouth vs. AFC Fylde or Wigan Athletic
Coventry City vs. Stoke City
Newport County vs Leeds United
Bolton Wanderers vs. Huddersfield Town
Port Vale or Yeovil Town vs. Bradford City
Nottingham Forest vs. Arsenal
Brentford vs. Notts County
Queens Park Rangers vs. MK Dons
Manchester United vs. Derby County
Forest Green Rovers or Exeter City vs. West Bromwich Albion
Doncaster Rovers vs. Slough Town or Rochdale
Tottenham Hotspur vs. AFC Wimbledon
Middlesbrough vs. Sunderland
Fleetwood Town or Hereford vs. Leicester City
Blackburn Rovers or Crewe Alexandra vs. Hull City
Cardiff City vs. Mansfield Town
Manchester City vs. Burnley
Shrewsbury Town vs. West Ham United
Wolverhampton Wanderers vs. Swansea City
Stevenage vs. Reading
Newcastle United vs. Luton Town
Millwall vs. Barnsley
Fulham vs. Southampton
Wycombe Wanderers vs. Preston North End
Norwich City vs. Chelsea
Gillingham or Carlisle United vs. Sheffield Wednesday