Bastian Schweinsteiger has been handed a rare opportunity in midfield, while left-back Luke Shaw has been given his first start since November.
Manchester United: Romero; Fosu-Mensah, Smalling, Rojo, Shaw; Fellaini, Schweinsteiger, Mkhitaryan, Mata, Martial; Rooney
Subs: Pereira, Blind, Tuanzebe, Herrera, Young, Ibrahimovic, Rashford
Wigan Athletic: Haugaard; Connolly, Buxton, Burn, Warnock; Power, Morsy, MacDonald, Perkins, Jacobs; Grigg
Subs: Jaaskelainen, James, Kellett, Tunnicliffe, Morgan, Wildschut, Browne
Follow the match live with Sports Mole's text commentary here.