Ashley Young has not travelled with Manchester United for their Champions League Group B tie against CSKA Moscow tomorrow night.
The winger missed United's 3-0 win at Everton on Saturday with a calf injury and is not part of Louis van Gaal's provisional squad for Wednesday's contest.
Luke Shaw, Paddy McNair and James Wilson are also out, but Sergio Romero and Antonio Valencia have travelled after sitting out the win at Goodison Park.
All four teams in the group have three points after two games.
United squad to face CSKA: De Gea, Romero, Johnstone, Darmian, Smalling, Jones, Rojo, Blind, Carrick, Schweinsteiger, Schneiderlin, Fellaini, Valencia, Pereira, Mata, Herrera, Memphis, Lingard, Rooney, Martial