United boss Jose Mourinho makes six changes from the side which beat Saint-Etienne on Wednesday, with David de Gea, Antonio Valencia, Marcos Rojo, Ander Herrera, Jesse Lingard and Anthony Martial all returning to the starting XI.
Instead, Maya Yoshida will partner Jack Stephens in defence, while Sofiane Boufal has recovered from an ankle problem to make the bench for the Saints, who are looking to secure the club's first major silverware in 41 years.
Southampton: Forster, Soares, Yoshida, Stephens, Bertrand, Romeu, Davis, Ward-Prowse, Tadic, Redmond, Gabbiadini
Subs: Long, Rodriguez, Cacares, Boufal, Hojbjerg, McQueen, Hassen
Manchester United: De Gea, Valencia, Bailly, Smalling, Rojo, Herrera, Pogba, Lingard, Mata, Martial, Ibrahimovic
Subs: Rooney, Carrick, Blind, Young, Rashford, Romero, Fellaini
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