Ole Gunnar Solskjaer's men have begun the 2020-21 campaign in dissatisfactory fashion, suffering home defeats to Crystal Palace and Tottenham Hotspur either side of a narrow victory at Brighton & Hove Albion.
The under-fire Red Devils currently lie 16th in the table at this early stage of the new campaign, four points and seven places below Newcastle heading into Saturday's gameweek four showdown.
However, the 20-time English champions have an added incentive to pick up a result here as they are looking to win their sixth top-flight away match while scoring more than once - a feat which they are yet to achieve in their illustrious history.
Solskjaer witnessed his players enjoy four away victories on the bounce at the end of the 2019-20 season, with Brighton, Crystal Palace, Aston Villa and Leicester City all falling victim to the Red Devils, who last tasted a Premier League defeat on the road in their 2-0 loss at Liverpool in January.
United's visit to the North East is followed up by a run of taxing fixtures against Paris Saint-Germain, Chelsea, RB Leipzig and Arsenal in the coming weeks.