The Blues are currently fourth in the division on 41 points, six points clear of ninth-placed United, who have won both matches between the two teams this season.
Frank Lampard's side have only lost one of their last eight matches in all competitions but have won just one of their last five in the league, drawing their last two with Arsenal and Leicester City.
Here, Sports Mole looks at how the capital side could line up at Stamford Bridge.
Ruben Loftus-Cheek, Christian Pulisic and Marco van Ginkel are still unavailable for selection through injury, but Tammy Abraham is being tipped to lead the Chelsea line on Monday night.
The England international has been struggling with an ankle problem but Lampard suggested that the striker would be available when addressing the media at his pre-match press conference.
Perhaps Lampard's biggest call will come between the sticks; Willy Caballero was given the nod against Leicester last time out due to Kepa Arrizabalaga's struggles, but the Spaniard is being tipped to return to the starting XI for the key Premier League encounter.
> Click here to see how Manchester United could line up for this fixture body check tags ::