The Red Devils have dropped to ninth position in the table having only won one of their last five in the league, although they are only six points off fourth-placed Chelsea as things stand.
United were held to a goalless draw by Wolverhampton Wanderers in their last match before the winter break, but Ole Gunnar Solskjaer's side have already beaten their opponents on Monday twice this season.
Here, Sports Mole looks at how the 20-time English champions could line up when they take to the field for the key Premier League clash.
United are still without the services of key midfielders Paul Pogba and Scott McTominay through injury, while Marcus Rashford will again be unavailable due to a back issue.
It seems likely that Solskjaer could use the same 3-4-1-2 formation that worked so well away to Manchester City in the second leg of their EFL Cup semi-final at the end of last month.
Odion Ighalo is unlikely to be thrown straight in for his debut, although the striker - signed on loan from Shanghai Shenhua last month - is expected to make the bench on Monday night.