Despite remaining just five points adrift of fourth-placed Chelsea, Ole Gunnar Solskjaer has watched his side lose at Arsenal and Liverpool since the turn of the year.
The Norwegian is also having to cope with a lengthy injury list, which has increased with Marcus Rashford being ruled out for the foreseeable future due to a back injury.
Here, Sports Mole predicts how United could line up for the showdown with the Clarets at Old Trafford.
Having only been used as a late substitute at Anfield on Sunday afternoon, Mason Greenwood is likely to be recalled to the starting lineup.
While the youngster is likely to feature on one of the flanks, Solskjaer may consider using him down the middle, leading to Anthony Martial moving out to the left.
Brandon Williams occupied that position against Liverpool, although the academy graduate is expected to drop back into his more familiar left-back role on Wednesday.
Given his showing versus Wolverhampton Wanderers in the FA Cup last week, the latter should get the nod, providing that Solskjaer does not deploy him on the wing.
The remainder of the first XI should remain the same, with Eric Bailly having to stay patient in his wait for a return to action after a serious knee injury. body check tags ::