Wednesday's EFL Cup victory over Chelsea handed Ole Gunnar Solskjaer's side their third consecutive away victory and added to the feeling that the Norwegian's tactical changes since the international break are working.
However, the Red Devils come up against a Bournemouth side that has only lost once at home - against Manchester City - so far this season.
Here, Sports Mole looks at how United could line up for Saturday's fixture.
Out: Paul Pogba (foot), Eric Bailly (knee), Timothy Fosu-Mensah (knee), Diogo Dalot (groin), Axel Tuanzebe (hip)
Doubtful: Marcus Rashford (knock), Harry Maguire (knock), Nemanja Matic (other), Luke Shaw (thigh), Victor Lindelof (knock)
In terms of formation, Solskjaer is likely to go back to the fluid 4-2-3-1 that saw United control the game and create spaces in behind during a 3-1 win over Norwich City last weekend, with three at the back serving as a more defensively-minded approach - used against Liverpool and Chelsea specifically to close down particular passing lanes.
Brandon Williams once again demonstrated that he could have a long-term future at Old Trafford with an accomplished performance at Chelsea. However, the left-back is likely to be once again swapped for Ashley Young as Solskjaer looks to rotate his options.
On the other side, Aaron Wan-Bissaka is fast becoming an indispensable member of the starting XI, consistently producing performances hallmarked by acute organisation, while Maguire and Lindelof are set to recover from slight knocks to start the game.
While the Brazilian is showing glimpses of his passing ability, McTominay has emerged as something of a leader in recent weeks, driving players forward through hard pressing and often winning important loose balls to prevent counter-attacks.
Another player coming into some good form is Andreas Pereira, whose control at close quarters and natural attacking instinct makes him a strong candidate to occupy the number 10 position on a long-term basis. The Brazilian was rested during the week, meaning that he is likely to start.
The attacking trio of Daniel James, Anthony Martial and Rashford holds some real promise, with Solskjaer's decision to allow the trio to interchange against Norwich opening up plenty of spaces in which to exploit the opposition.
Specifically, while James stays largely out wide and makes bursting diagonal runs, Rashford and Martial - two players with a strong chemistry - can alternate between occupying the left-hand side and forcing defenders into uncomfortable positions by making arcing runs on the last line of attack.
If the pair are able to interchange effectively, you would not bet against one of them getting on the scoresheet against Eddie Howe's men. body check tags ::