The Red Devils are currently just three points behind fourth-placed Chelsea in England's top flight following a 2-0 success at Stamford Bridge on Monday night.
Here, Sports Mole looks at how the 20-time English champions could line up this weekend.
Out: Paul Pogba (ankle), Marcus Rashford (back), Lee Grant (unspecified)
Doubtful: Scott McTominay (knee), Axel Tuanzebe (hamstring), Eric Bailly (knock), Timothy Fosu-Mensah (fitness), Mason Greenwood (illness)
United will again be unable to call upon either Paul Pogba or Marcus Rashford through injury, but Lee Grant, who has undergone surgery on an unspecified issue, is the the team's only other confirmed absentee heading into Sunday's contest.
Indeed, Scott McTominay could return to the squad for the first time since December having recently stepped up his recovery from a knee injury, while Eric Bailly, who was impressive against Chelsea on Monday night, will be hoping to shake off a knock to feature.
Mason Greenwood missed out against Brugge on Thursday through illness but should return to the squad. The teenager is an option to start alongside Anthony Martial in attack, although Odion Ighalo is pushing to make the first XI having been involved off the bench in United's last two.