Chelsea vs. Man City (Saturday, 12.30pm)
Chelsea top the table with 13 points to show from their opening five matches, while Man City occupy fifth, having collected 10 points from their first five league games of the 2021-22 campaign.
We say: Chelsea 1-1 Manchester City
It is still very early in the season, but there is simply no downplaying the importance of this match. Both managers will be desperate to put down a marker, but it is likely to be a tight and cagey affair at Stamford Bridge, and we have had to settle on a low-scoring draw, which both teams would probably take.
Man Utd vs. Aston Villa (Saturday, 12.30pm)
The Red Devils are currently third in the table, level on points with leaders Chelsea, while Villa occupy 10th position, having collected seven points from their opening five games of the campaign.
We say: Manchester United 3-1 Aston Villa
Villa's quality in attack means that they will fancy their chances of getting on the scoresheet at Old Trafford, but we cannot ignore the team's recent struggles against Man United in the Premier League. The Red Devils will be determined to bounce back from the disappointment of Wednesday's League Cup defeat to West Ham, and we are backing the home side to collect all three points here.
Everton vs. Norwich (Saturday, 3.00pm)
The two clubs also enter the contest on the back of top-flight losses, as Rafael Benitez's side went down 3-0 to Aston Villa while the Canaries also shipped three against Watford.
We say: Everton 2-0 Norwich City
Norwich supporters may be feeling quietly hopeful of a shock result at Goodison Park given their hosts' injury and confidence woes, and their recent results on the blue half of Merseyside have been encouraging.
However, Benitez's depleted side will view this encounter as a prime opportunity to get their European charge back on track, and we expect them to do just that this weekend.
Leeds vs. West Ham (Saturday, 3.00pm)
The Whites are currently 17th in the table, having picked up just three points from their opening five matches, while West Ham have collected eight points from their five games to sit eighth in the division.
We say: Leeds United 1-2 West Ham United
This is an incredibly difficult match to call, as it is tough to know what to expect from Leeds at the moment. It would not be a surprise to see a draw at Elland Road, but we just have a feeling for a West Ham side that continue to impress under Moyes and have therefore backed a narrow away success.
Leicester vs. Burnley (Saturday, 3.00pm)
We say: Leicester City 2-1 Burnley
Burnley frustrated Arsenal throughout the 90 minutes last week - although the Gunners arguably should have scored more on the day - while a red-hot Rodriguez could provide a new dimension to the visitors' attack.
Leicester have not dazzled and delighted in the early stages of the season and could struggle to impose themselves on the game once again, but we still have confidence in the hosts' ability to grind out a narrow win.
Watford vs. Newcastle (Saturday, 3.00pm)
Seeking to recover from their disappointing EFL Cup exit to lower-league opposition in midweek, Watford welcome Newcastle United to Vicarage Road in the Premier League on Saturday.
We say: Watford 2-2 Newcastle United
Neither Watford nor Newcastle have become renowned for low-scoring affairs this term, and we expect that trend to continue in a battle between two sides who will certainly view this fixture as winnable.
Munoz's side can hardly take inspiration from their midweek showing with a second-string XI, and Newcastle have had a full week to recuperate following last week's draw, so we can see a goal-fest of an encounter ending with both sides shaking hands on a point.
Brentford vs. Liverpool (Saturday, 5.30pm)
Both sides enter the contest having marched to convincing wins in their respective EFL Cup showdowns, with Thomas Frank's side putting seven past Oldham Athletic while the Reds eased to a 3-0 win over Norwich City.
We say: Brentford 0-2 Liverpool
Liverpool cannot expect to break down Brentford's staunch defence at will this weekend, and Klopp may have one eye on upcoming battles with Porto and Manchester City.
However, most of the visitors' big-hitters are well-rested and are simply flying away from home in the top flight, so we still expect Liverpool to record a straightforward win.