Premier League history was made in gameweek 20 as Manchester City became the ninth different team to end a day as league leaders courtesy of their 5-0 hammering of relegation-threatened West Bromwich Albion.
Third-placed Leicester City also dropped points in their draw with Everton, allowing champions Liverpool to close the gap on the top three by returning to winning ways at the expense of Tottenham Hotspur.
Chelsea's Thomas Tuchel era began with a goalless draw against Wolverhampton Wanderers, while Burnley won a topsy-turvy affair against Aston Villa and Brighton & Hove Albion vs. Fulham ended goalless.
Here, Sports Mole selects its Premier League team of the week for gameweek 20.
For the second time this season, Burnley had Nick Pope to thank for getting something from a game against Aston Villa, with the keeper again in fine form to set up the foundations for his side's 3-2 win.
However, he narrowly misses out on a place in this week's team to Fulham shot-stopper Alphonse Areola, whose clean sheet gives him the edge. Areola made five saves to keep Brighton at bay, including a fine one late on to earn his side a point.
That save could have been worth even more had Fulham nicked a victory even later on, but they were denied that by Lewis Dunk's goalline clearance at the death.
Sheffield United's centre-backs also deserve mentions for their role in the stunning win at Old Trafford, and Phil Jagielka does make the cut having led the Blades' resistance.
Cancelo scored one and created another in Man City's rout of West Brom, a haul Trent Alexander-Arnold matched as Liverpool rounded off the gameweek with victory at Spurs.
The deeper midfield positions were also straightforward choices in this week's team, with Ilkay Gundogan and Tomas Soucek both getting on the scoresheet twice apiece.
Gundogan was arguably the standout performer out of many candidates for that mantle in Man City's win over West Brom, while Soucek was also a shoo-in, but there was plenty of competition in the middle of the park with Declan Rice, John Fleck and John Lundstram among those worthy of a mention.
The most competitive places in this week's XI came in the trio behind the striker, though, meaning that the likes of Raheem Sterling, Jack Grealish and Dwight McNeil miss out despite fine performances.
Bukayo Saka, Raphinha and Sadio Mane all helped themselves to a goal and an assist in their respective matches, though, with the latter also having a major say in Liverpool's other goal against Tottenham, and the decisive nature of their contributions is ultimately what earns them the nod above the numerous other candidates for the roles.