Toby Alderweireld has come in for Eric Dier as Tottenham Hotspur visit Manchester United this afternoon.
Mauricio Pochettino names an otherwise-unchanged side from the 5-0 hammering of Swansea City in the league last time out, with Alderweireld joining Kyle Walker, Jan Vertonghen and Danny Rose in the back four.
Harry Kane continues up front with support from Christian Eriksen, Dele Alli and Son Heung-min.
Meanwhile, United boss Jose Mourinho fields an unchanged lineup from the 1-1 draw at Everton, with Zlatan Ibrahimovic up front supported by Henrikh Mkhitaryan, Paul Pogba and Anthony Martial.
The fit-again Eric Bailly only makes the bench, where he is joined by captain Wayne Rooney, Marcus Rashford, Juan Mata and Marouane Fellaini.
Manchester United: De Gea; Darmian, Rojo, Jones, Valencia; Carrick, Herrera; Mkhitaryan, Pogba, Martial; Ibrahimovic
Subs: Romero, Bailly, Blind, Fellaini, Mata, Rashford, Rooney
Tottenham Hotspur: Lloris; Walker, Alderweireld, Vertonghen, Rose; Wanyama, Dembele; Eriksen, Dele, Son; Kane
Subs: Vorm, Wimmer, Davies, Dier, Winks, Sissoko, Nkoudou
Keep up with all of the action from Old Trafford this afternoon with Sports Mole's live text commentary here.