Liverpool manager Jurgen Klopp may be without no fewer than 10 players for Thursday's Premier League battle with Manchester United at Old Trafford.
Virgil van Dijk, Joe Gomez and Joel Matip continue to recuperate from their long-term injuries, and the Reds also had to cope without two more injured centre-backs in Ozan Kabak and Ben Davies against Southampton.
However, Rhys Williams and Nat Phillips kept a clean sheet in that 2-0 win and look set to pair up once again, with Trent Alexander-Arnold and Andy Robertson bombing down the flanks.
There should be no surprises in the midfield, with Fabinho, Georginio Wijnaldum and Thiago Alcantara - who bagged his first Liverpool goal against the Saints - keeping Curtis Jones and Alex Oxlade-Chamberlain out of the team.
Naby Keita has suffered another setback in his return from injury, meanwhile, while veteran midfielder James Milner is struggling with a minor problem and is unlikely to be risked at Old Trafford.
Divock Origi is also out injured, but Diogo Jota's spot is nevertheless at risk from Roberto Firmino, with 20-goal Mohamed Salah indispensable on the right flank.
Sadio Mane is enduring the "worst season" of his career by his own admission, but the Senegal international will have the chance to hit double figures in terms of goals for the Premier League campaign at Old Trafford.
Liverpool possible starting lineup: Alisson; Alexander-Arnold, Phillips, Williams, Robertson; Fabinho, Thiago, Wijnaldum; Salah, Firmino, Mane
> Click here to see how Man United could line up for this clash
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