Virgil van Dijk, Joe Gomez and Joel Matip continue to recuperate from their long-term injuries, and the Reds also had to cope without two more injured centre-backs in Ozan Kabak and Ben Davies against Southampton.
There should be no surprises in the midfield, with Fabinho, Georginio Wijnaldum and Thiago Alcantara - who bagged his first Liverpool goal against the Saints - keeping Curtis Jones and Alex Oxlade-Chamberlain out of the team.
Sadio Mane is enduring the "worst season" of his career by his own admission, but the Senegal international will have the chance to hit double figures in terms of goals for the Premier League campaign at Old Trafford.
Liverpool possible starting lineup: Alisson; Alexander-Arnold, Phillips, Williams, Robertson; Fabinho, Thiago, Wijnaldum; Salah, Firmino, Mane
Watch the Sports Mole Football Shorts prediction for this game below:
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