Marcus Rashford has only been named on the Manchester United substitutes' bench for Thursday's Premier League game against Chelsea.
The forward has missed the last two games through a minor injury and illness, but he had been expected to return to the starting XI for the match at Old Trafford.
However, Erik ten Hag has instead retained the same side that began the 1-0 victory over Bournemouth at the Vitality Stadium over the weekend.
In sharp contrast, Chelsea caretaker manager Frank Lampard has made three changes in personnel and switched to a back four.
Despite Chelsea giving a solid account of themselves in a 1-0 defeat at champions Manchester City on Sunday, Lampard has selected Wesley Fofana and Trevoh Chalobah as his two central defenders with Thiago Silva dropping to the substitutes' bench.
Carney Chukwuemeka has been handed just his second Premier League start for Chelsea in midfield, while Noni Madueke and Mykhaylo Mudryk have been restored to the flanks.
Ruben Loftus-Cheek is only named as a replacement, while Raheem Sterling does not feature in the squad altogether, presumably due to the hamstring issue that has led to him not being named in the recent England squad.
Joao Felix is fit enough to be selected on the bench after a knock, while young centre-back Alfie Gilchrist is also included in the nine-strong selection kept in reserve.
Manchester United: De Gea; Wan-Bissaka, Varane, Lindelof, Shaw; Casemiro, Eriksen; Antony, Fernandes, Sancho; Martial
Subs: Butland, Dalot, Maguire, Malacia, Fred, McTominay, Garnacho, Rashford, Weghorst
Chelsea: Arrizabalaga; Azpilicueta, Chalobah, W. Fofana, Hall; Gallagher, Fernandez, Chukwuemeka; Madueke, Havertz, Mudryk
Subs: Mendy, Silva, Pulisic, Felix, Loftus-Cheek, Ziyech, Koulibaly, D. Fofana, Gilchrist