Montpellier HSC boss Jean Fernandez has made a triple swap to the side that drew at Nice in their last Ligue 1 match.
Geoffrey Jourdren, Morgan Sanson, Yassine Jebbour all come into the first XI in place of Laurent Pionnier, Daniel Congre and Anthony Mounier.
Meanwhile, Reims coach Hubert Fournier has opted for two changes to his team following their goalless draw with Nantes last time out.
Eliran Atar and Prince Oniangue drop out, with Grzegorz Krychowiak and Gaetan Courtet being favoured.
Montpellier: Jourdren, El Kaoutari, Hilton, Jebbour, Mezague, Tiene, Cabella, Sanson, Stambouli, Camara, Montano
Reims: Agassa, Glombard, Mandi, Tacalfred, Weber, Albaek, Devaux, Krychowiak, Charbonnier, Courtet, Fortes
