The 34-year-old missed Wednesday's 2-1 victory away at Metz, after a scan revealed bone bruising on his left knee, and he is also a major doubt for their Champions League encounter with Manchester City next week.
Mauricio Pochettino has at least four other players ruled out for this weekend's fixtures, as Sergio Ramos (calf), Marco Verratti (knee), Juan Bernat (ACL) and Ismael Gharbi (thigh) continue to recover from their respective injuries.
Pochettino is expected to tinker with his starting lineup in a few positions due to their busy fixture schedule.
Achraf Hakimi – who scored a brace in midweek – as well as Marquinhos and Presnel Kimpembe are expected to remain in defence, while Keylor Navas could once again keep the number one jersey ahead of summer signing Gianluigi Donnarumma.
PSG possible starting lineup: Navas; Hakimi, Marquinhos, Kimpembe, Diallo; Danilo, Herrera, Wijnaldum; Neymar, Icardi, Mbappe body check tags ::