The Netherlands are on the brink of failing to qualify for Euro 2016 as the 10 men of Czech Republic hold a 2-0 lead over Danny Blind's men at the break in their clash.
The Oranje threatened in the first minute when Klaas-Jan Huntelaar sent a through ball for Anwar El-Ghazi, who cut back onto his left foot before shooting at goal, only to see his effort well saved by Petr Cech.
El-Ghazi threatened again for the home side when he raided down the left and lifted the ball into the box for the run of Wesley Sneijder, but he sent his effort over the bar.
Despite the early chances for the Netherlands, they fell behind in the 24th minute when Jiri Skalak released the run of Pavel Kaderabek behind the home side's defence and the defender slotted the ball past Jeroen Zoet.
Czech Republic doubled their lead in the 34th minute when Josef Sural ran at the Netherlands defence before raiding past Virgil van Dijk and sliding his effort beyond the reach of Zoet.
However, the visitors were reduced to 10 men just before half time when Marek Suchy was dismissed for bringing down Memphis Depay when the forward was about to break towards goal, giving Blind's men hope for the second half.