Oxford Utd vs. Reading (Saturday, 12.30pm)
The relegation zone competes against the playoffs on Saturday when Oxford United and Reading meet in their latest League One clash.
The two teams are at complete opposite ends of the table and require points for drastically different reasons in what is a crucial game for each.
We say: Oxford United 0-1 Reading
Oxford United will be the favourites walking into this weekend due to the league positions of each club, but recent form tells a different story.
Reading have been grinding out results against some of League One's strongest teams lately, and Saturday could provide another upset.
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Bolton vs. Barnsley (Saturday, 3.00pm)
Bolton Wanderers will welcome Barnsley to Lancashire on Saturday in a key contest at the top end of the League One table.
The two teams are currently separated by five points, with the hosts sat in the automatic promotion spots and their visitors remaining fifth after a disappointing defeat last weekend.
We say: Bolton Wanderers 2-1 Barnsley
We anticipate a close encounter between two sides full of quality on Saturday but give a slight edge to the hosts, who have more momentum on their side and their sights set on taking top spot in the coming weeks.
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Burton Albion vs. Lincoln (Saturday, 3.00pm)
Burton Albion will be aiming to move level on points with Lincoln City in League One by beating them at Pirelli Stadium on Saturday.
The visitors have failed to win any of their last nine league games, with five of those matches ending as draws.
We say: Burton Albion 0-0 Lincoln City
Both of these teams prefer to soak up possession before hitting their opponents in transition, meaning they may struggle to adapt to taking the game to each other on Saturday.
They were both involved in 0-0 stalemates last weekend, and we would not be surprised to see another one play out at Pirelli Stadium.
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Charlton vs. Derby (Saturday, 3.00pm)
Derby County will be looking to claim a second consecutive victory when they travel to The Valley for Saturday's League One clash with Charlton Athletic.
The visitors, who currently occupy 18th place, will be desperate to end their poor run of form, having failed to win any of their last 11 league matches.
We say: Charlton Athletic 1-2 Derby County
Derby have tended to enjoy themselves on their travels this season, and we think they will produce another successful away performance when they face a Charlton side low on confidence following an 11-game winless league run.
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Cheltenham vs. Wycombe (Saturday, 3.00pm)
Cheltenham Town will be aiming to bounce back from successive defeats in League One when they host Wycombe Wanderers on Saturday.
The visitors will head into the encounter four points clear of the relegation zone, and eight points ahead of Cheltenham.
We say: Cheltenham Town 1-1 Wycombe Wanderers
Wycombe have been one of the draw specialists in League One in recent weeks, drawing six of their last nine games. They would likely take another point on Saturday in order to maintain their eight-point lead over Cheltenham in the table.
Given that Cheltenham have lost their last two matches, they could be forgiven for accepting avoiding defeat, too. However, time is running out for them to start putting wins on the board in order to survive this season, but we can see these sides sharing the spoils.
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Exeter vs. Bristol Rovers (Saturday, 3.00pm)
Exeter City will be hoping to earn a third successive victory when they host Bristol Rovers in League One on Saturday.
The visitors, meanwhile, ended a four-match losing streak by beating Oxford United last weekend.
We say: Exeter City 1-2 Bristol Rovers
Bristol Rovers' matches are usually high scoring, and with Exeter rediscovering some decent form since returning to winning ways on Boxing Day, we see no reason why this meeting would be any different.
Exeter defeated the Gas very recently in a rescheduled fixture, but we can envisage the visitors gaining some revenge after putting in a good performance when beating Oxford last time out.
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Fleetwood vs. Port Vale (Saturday, 3.00pm)
Fleetwood Town will attempt to end a 14-game game unbeaten in all competitions when they welcome Port Vale to Highbury Stadium for Saturday's contest.
Like their hosts, Port Vale will also be desperate to claim all three points after failing to win any of their last three matches.
We say: Fleetwood Town 1-1 Port Vale
Both teams will be determined to claim three points to assist their survival efforts, but with the two sides finding wins hard to come by, we think they will have to settle for a share of the spoils in Saturday's contest.
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Leyton Orient vs. Carlisle (Saturday, 3.00pm)
Carlisle United's quest to secure survival in League One continues this Saturday when they make the trip to face Leyton Orient.
The hosts are currently in 10th place and head into the match on the back of a six-match run without a defeat.
We say: Leyton Orient 3-0 Carlisle United
This match looks routine on paper due to the recent form and league positions of both teams, and while anything can happen in football it should be a simple win for Leyton Orient.
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Peterborough vs. Wigan (Saturday, 3.00pm)
Peterborough United return to action in the League One when they go head to head with Wigan Athletic at the Weston Homes Stadium on Saturday evening.
Both sides head into the weekend off the back of contrasting results, with the Posh claiming a third home win on the spin and the visitors suffering a narrow home defeat at the hands of Stevenage.
We say: Peterborough United 2-1 Wigan Athletic
While Wigan will be looking to return to winning ways, they are in for a tough 90 minutes against a spirited Peterborough side. The Posh have won their last three home games and we fancy them to come out on top this weekend.
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Portsmouth vs. Northampton (Saturday, 3.00pm)
Portsmouth will attempt to extend their unbeaten run to four matches when they welcome Northampton Town to Fratton Park on Saturday.
The hosts are currently sitting top of the League One table, while the visitors head into the weekend in ninth position.
We say: Portsmouth 3-1 Northampton Town
With the Cobblers struggling with injuries, they could probably do without an away game against the current league leaders.
While they may have lost just one of their last five away league matches, Northampton have lost each of their previous four away meetings with Portsmouth, and we think that run will continue with a defeat on Saturday.
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Shrewsbury vs. Cambridge (Saturday, 3.00pm)
Separated by just a single point in the third-tier standings, Shrewsbury Town will do battle with Cambridge United at The Croud Meadow on Saturday afternoon in League One.
The Shrews ended their losing run with an away success at Northampton Town last time out, while the U's were forced to share the spoils with Burton Albion.
We say: Shrewsbury Town 2-1 Cambridge United
Shrewsbury were impressive during their win at Northampton last time out, and Hurst's men will be confident of recording back-to-back victories in League One.
Cambridge are beginning to stutter in this third-tier campaign, and we are envisaging another tough away out for the U's on Saturday afternoon.
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Stevenage vs. Blackpool (Saturday, 3.00pm)
Fresh off the back of reaching the EFL Trophy semi-finals, Blackpool journey to the Lamex Stadium to take on Stevenage in round 31 of the League One on Saturday.
Having lost each of the last three meetings between the sides, Boro will head into the weekend desperate to get one over the visitors and move into the promotion playoff places.
We say: Stevenage 2-1 Blackpool
With just three points separating Stevenage and Blackpool, we anticipate a thrilling contest between the sides in a race for a playoff spot. Boro have been rock-solid at home in recent weeks and we see them scraping all three points in front of their home supporters.