They will shield 37-year-old goalkeeper Antony Silva, who put in an eye-catching performance during the recent 1-0 defeat to Uruguay to keep his nation in the game.
Alejandro Romero will hope for a return to the starting XI, although his two consecutive games on the bench could see him again used as a substitute on Friday.
Meanwhile, Braian Samudio should keep his place on the wing, having scored the opening goal in their crucial 2-0 win over Chile.
The trio of Almiron, Romero and Samudio could operate behind the focal point of Gabriel Avalos, who offers plenty of experience going forward.
Paraguay possible starting lineup: Silva; Espinola, Gomez, Alonso, Alderete; Villasanti, Gimenez; Romero, Almiron, Samudio; Avalos
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