Wednesday will see two of the teams near the foot of the Championship compete as Hull City host Peterborough United, who currently sit in the relegation zone.
The hosts are only a single point away from that themselves, meaning a victory for the visitors would drag the Tigers into it, making this a crucial fixture for both clubs.
Match preview
After securing only their second victory of the season in the final game before the recent international break, Hull City were unable to continue their momentum at the weekend when they faced Huddersfield Town.
The Tigers had picked up four points in their previous two matches with a draw against Blackpool being followed up by a 2-0 win when they played Middlesbrough.
But Saturday proved to be a difficult test for Grant McCann's men, losing 2-0 against the Terriers, even though they dominated the possession throughout the game.
It has been a tough season for Hull City, which is why they sit just a point above the relegation zone with Barnsley and Peterborough United breathing down their necks.
Even though the Tigers won League One in the 2020-21 campaign to earn promotion, adapting to the Championship has proved to be a tough task.
However, they have kept close enough to several of the teams above them and because of that, a win has the potential to see them climb as high as 16th.
Peterborough United finished just two points behind Hull City last season as they enjoyed automatic promotion alongside their upcoming opponents, but they have also found life in a higher division hard.
The visitors could escape the relegation zone themselves if they are victorious on Wednesday depending on other results, and keeping the same distance from Derby County would also be important.
However, Peterborough United have not won in their last four games and only have two to their name for the entire season, with their most recent outing ending in a 2-0 defeat.
Darren Ferguson's team have only scored in one fixture on their recent run without three points, which has been a big cause of their problems so far in this campaign.
However, an even bigger issue for the Posh is the fact they have conceded 25 goals in the opening 12 fixtures, which is more than any team in the Championship.
Last season, each team managed a victory across their two meetings and with so much riding on this particular match, there is real importance for three points from both sides.
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Team News
Hull City welcomed back George Honeyman for the recent loss against Huddersfield Town, although he was unable to play the entire 90 minutes.
However, the Tigers were still missing experienced central midfielder Tom Huddlestone, who was not able to return from injury, although he has been training throughout the international break, which should see him back soon.
McCann will be without Alfie Jones for the upcoming game, though, as he continues to work his way back from a hamstring issue.
Peterborough will also be missing key players as both Jack Marriott and Joel Randall continue to be unavailable, with the attackers dealing with long-term injuries at the minute.
Hull City possible starting lineup:
Ingram; Elder, Greaves, Bernard, Coyle; Cannon, Smallwood; Lewis-Potter, Honeyman, Wilks; Smith
Peterborough United possible starting lineup:
Cornell; Thompson, Knight, Edwards, Beevers, Butler; Grant, Norburn, Taylor, Szmodics; Dembele
We say: Hull City 2-2 Peterborough United
This game is crucial for both teams, but it is also one that neither will want to lose and because of that it could end up being one that is played very cautiously.
That is why they could end up sharing the spoils with a draw, in a match that is likely to feature some goals due to the poor defensive record of each squad.
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