Port Vale manager Rob Page has made two changes to the side which beat Burnley in the Capital One cup earlier this week, with Uche Ikpeazu and Ryan Inniss coming in for AJ Leitch-Smith and Remie Streete.
Meanwhile, Gillingham have made changes to the side which battered Sheffield United 4-0 last weekend with Bradley Garmston, Josh Wright and Luke Norris coming in for the Gills.
Port Vale: Alnwick; Purkiss, Dickinson, Inniss, Duffy, Grant, Foley, Moore, Andoh, Dodds, Ikpeazu
Gillingham: Nelson; Jackson, Egan, Oshilaja, Garmston; Houghton, Wright, B Dickenson, Dack; Norris, Williamson